Women’s cardiovascular health remains an urgent clinical unmet need, as cardiovascular disease risk in women, particularly those aged 40-60, is often underestimated by both clinicians and women themselves. This leads to cardiovascular diseases being underdiagnosed, undertreated, and poorly understood in this population, despite the potential for personalized risk assessment and prevention to improve health outcomes. Therefore, the goal of the CARAMEL project is to deliver an innovative personalized prevention model for women aged 40-60, using a risk assessment stratification approach that incorporates sex- and gender-specific risk factors alongside self-assessment and self-management supported by cutting-edge digital technologies.